Fibrin Monomer Induces Binding of Endogenous Platelet von Willebrand Factor
نویسندگان
چکیده
This study demonstrates that when platelets are stimulated by thrombin in the presence of low concentrations of purified human fibrinogen (10 to 20 Lg/mL. final concentration) binding of released platelet von Willebrand factor (plt-vWF) to the platelet membrane is enhanced. This effect appears to be mediated by fibrin monomer produced by the action of thrombin on the fibrinogen in the incubation suspension. When fibrin polymerization is inhibited. the binding of released plt-vWF to the platelets is markedly increased. This enhanced binding is dependent on platelet glycoprotein lb (GPIb) as shown by a decreased response with Bernard-Soulier platelets and inhibition by both mono-
منابع مشابه
Fibrin Monomer Induces Binding of Endogenous Platelet von Willebrand Factor to the Glycocalicin Portion of Platelet Glycoprotein lB
This study demonstrates that when platelets are stimulated by thrombin in the presence of low concentrations of purified human fibrinogen (10 to 20 Lg/mL. final concentration) binding of released platelet von Willebrand factor (plt-vWF) to the platelet membrane is enhanced. This effect appears to be mediated by fibrin monomer produced by the action of thrombin on the fibrinogen in the incubatio...
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This study demonstrates that when platelets are stimulated by thrombin in the presence of low concentrations of purified human fibrinogen (10 to 20 micrograms/mL, final concentration) binding of released platelet von Willebrand factor (plt-vWF) to the platelet membrane is enhanced. This effect appears to be mediated by fibrin monomer produced by the action of thrombin on the fibrinogen in the i...
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